Author

Li-Dan Yang

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Open access Sep 2026

Identification of Mitochondrial-Lipid Metabolism-Related Diagnostic Targets in Osteoarthritis: Integrative Multi-omics Data and Experimental Validation

Objective Osteoarthritis (OA) is a degenerative joint disease associated with metabolic dysregulation. This study aims to identify mitochondrial-lipid metabolism-related hub genes and explore their mechanisms in OA. Methods Training (GSE55235) and validation (GSE55457 and GSE82107) cohorts were retrieved from the Gene...

Miao Huang, Xu-Tai Tan, Ji-bin Yang et al. · bioRxiv · 0 citations

Review Open access Sep 2026

Context-dependent roles of the NLRP3 inflammasome in osteomyelitis and strategies for precision modulation

It is proposed that future NLRP3-targeted therapy for osteomyelitis should shift from “non-specific anti-inflammation” to “bone immune reprogramming”—stratified intervention based on infection stage, cell type, and inflammasome activation level, integrating NLRP3 modulation with antibacterial, anti-biofilm, anti-pyropt...

Li-Dan Yang, Lin Zhang, Xu-Xu Yang et al. · Frontiers in Immunology · 0 citations