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Author

Li-Dong Zhang

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Sep 2026

SIRT1 Activation Ameliorates Neuroinflammation and Cognitive Impairment in a Murine SAE Model and is Associated with the Nrf2/GPX4 Pathway

It is demonstrated that SIRT1 activation improves survival and ameliorates cognitive deficits by concurrently attenuating hippocampal ferroptosis and neuroinflammation, and suggest SIRT1 activation coordinately counteracts both ferroptotic and inflammatory damage in SAE.

Yue Zhang, Qingzhen Liu, Haishu Zhao et al. · 0 citations
Open access Jan 2026

Mendelian Randomization and Transcriptome Analysis Identify Ischemic Stroke Biomarkers With Putative Relevance to Cerebrospinal Fluid

Background Circulating proteins have been associated with the pathogenesis of ischemic stroke (IS), yet its biomarkers remain underutilized. Using plasma protein GWAS data with putative relevance to CSF, this study integrated mendelian randomization (MR) and transcriptomics to identify potential IS biomarkers. Methods...

Jingwei Xiong, Jie Zhang, Xuemei Cheng et al. · 0 citations

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