Childhood-Onset Systemic Lupus Erythematosus: Genetic Mechanisms and Therapeutic Strategies.
OBJECTIVE Childhood-onset systemic lupus erythematosus (cSLE) is more aggressive than adult SLE, with higher rates of lupus nephritis, organ damage, and early mortality. This review synthesizes recent advances in cSLE genetics and targeted therapies. METHODS We conducted a comprehensive literature search in PubMed an...