Ulcerative colitis (UC) is an intestinal inflammatory disorder primarily driven by M1 macrophage activation and oxidative stress. p62/Sequestosome-1, a multifunctional autophagy adaptor protein, plays a critical role in regulating autophagy and inflammation. α-Methylene-γ-butyrolactone (αMγB), a conserved structural mo...
The genus Atractylodes (Asteraceae) is widely distributed and utilized in East and Southeast Asia, particularly in China, Japan, Korea and Thailand. In traditional Chinese medicine, representative species such as A. lancea and A. macrocephala have historically been employed to strengthen the spleen and eliminate dampne...
Siwei Luo, Jia-Meng Jiang, Dong-Mei Zhang et al.· Chinese Medicine· 1 citation
Novel guaianolide sesquiterpenoid CI was identified as an affinity-dependent dual-target regulator of STK11 and PP2Ac α with low affinity to inhibit AMPK activation to alleviate DILI.
Fei Zhou, Yu Liu, Hao-Yu Zhao et al.· Journal of Advanced Research· 0 citations
Findings establish GDD as a first-in-class APPL1 activator that reprograms mitochondrial homeostasis and reinstates insulin signaling, providing proof of concept for pharmacological targeting of APPL1 as a novel anti-diabetic strategy.
Hao Zheng, Ya-Ru Zhao, Xian-Yan Deng et al.· Phytomedicine· 0 citations
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