Li-Hong Yu

Resampling-Iteration-Evolution (RIE): A Rational Design System for Engineering High-Affinity Peptides against Small Molecules.

Peptides are attractive molecular recognition elements because of their compact size, ease of modification, and structural tunability. The design of high-affinity peptides for small molecules lags far behind that of antibodies and aptamers due to the lack of general and effective discovery and optimization strategies....