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Li-Jian Chen

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Open access Oct 2026

integrating single-cell transcriptomics and chromatin accessibility profiling to decipher the molecular landscape of Hepatocellular carcinoma

Background Hepatocellular carcinoma (HCC) is a prevalent and lethal liver malignancy, characterized by high recurrence rates and limited therapeutic options. Current diagnostic and treatment strategies are hindered by drug resistance and a lack of effective biomarkers for early detection. Methods This study aims to elu...

Kai-Le Pan, Li-Jian Chen, Yi-Tao Zheng · 0 citations
Open access Oct 2026

Tryptophan metabolism-derived prognostic signature: A potential biomarker for risk stratification and exploratory immunotherapy relevance analysis in prostate cancer.

ObjectiveProstate cancer (PCa) lacks reliable biomarkers to distinguish indolent from aggressive tumors. Tryptophan metabolism (TM) participates in regulating tumor immunity and malignant progression, yet its prognostic relevance in PCa remains poorly characterized.MethodsTranscriptomic and clinical data of TCGA-PRAD c...

An-Ding Gao, Yi-Chen Xu, Ting-Ting Wang et al. · 0 citations

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