Author

Li Jiang

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Open access Sep 2026

Global, Regional and National burden of dementia attributable to metabolic dysregulation from 1990 to 2021, with projections of burden to 2050: An analysis of the global burden of disease study 2021.

BACKGROUND AND AIMS We quantified dementia burden attributable to high fasting plasma glucose (FPG) and high body mass index (BMI), projected trends to 2050, and examined metabolic traits using Mendelian randomization (MR). METHODS Global Burden of Disease (GBD) 2021 data from 204 countries and territories were analy...

Kai-Chen Wang, Mei-Jin Song, Jing Lu et al. · Diabetes & metabolic syndrom... · 0 citations

Open access Aug 2026

Cerebral amyloid-β burden and white matter injury: associations, clues for underlying mechanisms, and implication on cognitive trajectory after lecanemab therapy.

The interplay of Aβ with white matter integrity contributes to cognitive decline in the context of Alzheimer's disease, with greater cognitive improvement observed among those with smaller WMH reductions.

Ke Shi, Xin-Yu Luo, Tong-Tong Liu et al. · Journal of Advanced Research · 0 citations

Open access Aug 2026

Jianpi Yiqi Busui Formula attenuates immune dysregulation in myasthenia gravis: Associations with gut microbiota remodeling and the Treg LDHA-lactate-H3K18la-PD-1 axis.

The findings support a coordinated model in which gut microbiota remodeling and LDHA-dependent Treg immunometabolic changes contribute to the effects of JPYQBSF.

Yi-Bin Zhang, Qinan Lu, Lei Wu et al. · Phytomedicine · 0 citations

Review Open access Aug 2026

Microglia-mediated neuroinflammation in Alzheimer’s disease: mechanisms and emerging therapeutic targets

A “cellular state–pathological network–therapeutic window” framework is proposed and the roles of microglia in amyloid-β plaque seeding and compaction, NLRP3 inflammasome activation, mitochondrial DNA–cGAS–STING signaling, complement-mediated synaptic engulfment, and bidirectional microglia–tau feedback are systematica...

Lian-Jing Xu, Ying Zhang, Li Jiang et al. · Frontiers in Cellular Neuros... · 0 citations