Chronic kidney disease (CKD) has become a global public health issue, with progressive kidney fibrosis serving as a key pathological process leading to kidney failure, and current therapeutic approaches remain largely ineffective in reversing this progression. SIRT1, as an NAD⁺-dependent deacetylase, plays a central pr...
Yu-Cheng Han, Qian-Wei Wang, Xuan-Bing Pan et al.· Frontiers in Medicine· 0 citations
Gut microbiota exert core regulatory effects on systemic metabolic homeostasis and immune balance under physiological and pathological conditions. Marked gut dysbiosis occurs during the progression of chronic kidney disease (CKD), characterized by abnormal enrichment of opportunistic pathogens and depletion of benefici...
Qian-Wei Wang, Jiahe Zhang, Ruiyan Chen et al.· Frontiers in Pharmacology· 0 citations
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