Author

Li-Jun Chen

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Open access Aug 2026

Early cardiac proteomic profiling in a long-latency doxorubicin cardiomyopathy model exhibits sexual dimorphism for cardioprotection

Anthracycline-induced cardiotoxicity remains a major limitation in cancer therapy, with substantial inter-individual variability in susceptibility, including documented sex differences. However, the molecular basis underlying these disparities remains incompletely understood. In this study, we employed large-scale data...

Sogol Sedighi, Li-Jun Chen, Yue-Fen Wang et al. · Journal of Molecular and Cel... · 0 citations

Open access Sep 2026

Proteogenomic analysis of pediatric and AYA high-grade glioma reveals age-dependent biology, female-male differences, and kinase targets.

High-grade gliomas (HGGs) in children and adolescents and young adults (AYA) exhibit distinct biology across the neurodevelopmental spectrum. To dissect tumor-intrinsic molecular characteristics independent of developmental variation, we perform comprehensive proteogenomic analyses of tumors from 112 HGG patients aged...

N. Tignor, M. Koptyra, Shrabanti Chowdhury et al. · Cell Reports Medicine · 0 citations