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Li-Jun Yao

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Oct 2026

Skeletal Muscle DPT Ameliorates Obesity and Metabolic Dysfunction via the PERK/eIF2α/ATF4-GDF15 Axis.

ARTICLE HIGHLIGHTS We identified dermatopontin (DPT) as a previously unrecognized compensatory regulator that is upregulated in skeletal muscle in obesity and preserves muscle function and systemic metabolic homeostasis, offering a potential therapeutic target for metabolic disorders. Mechanistically, DPT activates an...

Ling-Xin You, Bo Xu, Ting-Ting Wen et al. · 0 citations

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