Author

Lili Jiang

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Open access Oct 2026

RBM4 Stabilizes S100A10 mRNA to Remodel the Tumor Immune Microenvironment and Promote Immune Evasion in Hepatocellular Carcinoma.

RNA-binding protein RBM4 regulates post-transcriptional programs, but its role in shaping the hepatocellular carcinoma (HCC) tumor immune microenvironment (TIME) is unclear. We hypothesized that RBM4 enhances S100A10 mRNA stability to drive immune evasion. RBM4-S100A10 coupling was interrogated by expression profiling,...

Yi-Wen Zhang, Lan-Lan Gui, Yan-Rong Lu et al. · Molecular Carcinogenesis · 0 citations

Open access Aug 2026

Discovery of a Potent and Selective KRAS G12D Degrader based on PROTAC Degradation.

This work designed and synthesized 20 novel KRAS G12D PROTACs based on the MRTX1133 derivative and found that compound VI-1 exhibited significant KRAS G12D degradation activity in PANC-0203 cells, achieving 69% effective degradation at 10 μM.

Lili Jiang, Wenyan Yang, Yan-Qing Liu et al. · European Journal of Pharmace... · 0 citations