Author

Liling Hao

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Aug 2026

Enzyme/Nanozyme Cascade Catalysis-Driven Trimodal Platform Using a Readily Prepared Single-Component Nanozyme for Highly Efficient Metabolic Biomarker Assays.

Nanozyme-based biosensors have aroused much attention in recent decades and were broadly applied to multifarious areas. Whereas, the inferior reliability and high cost/complexity induced by the limited-modal outputs and commonly used multicomponent nanozymes in existing works are still drawbacks that cannot be ignored....

Juan Wang, Hengqian Zhang, Li-Ling Hao et al. · Analytical Chemistry · 0 citations

Aug 2026

Biphasic spatiotemporal regulation of Cas12a substrate cleavage enables one-pot autocatalytic CRISPR biosensing of non-nucleic-acid targets.

One-pot autocatalytic CRISPR biosensing offers a promising route for signal amplification without nucleic acid pre-amplification, but its efficiency is limited by an intrinsic readout-amplification conflict: the ssDNA reporter required for signal output competes with the autocatalytic mediator required for feedback amp...

Tai Ye, Mei Xue, Bing-Jing Zhou et al. · Biosensors & bioelectronics · 0 citations