Research Progress on Drp1 in the Pathological Mechanisms and Therapeutic Interventions of Stroke, Based on the Imbalance in the Dynamic Equilibrium of Mitochondrial Fission and Fusion.
Ischemic and haemorrhagic strokes together constitute the leading cause of death and disability worldwide, and their pathological mechanisms involve an imbalance in mitochondrial dynamics. Dynamin-related protein 1 (Drp1), a key GTPase driving mitochondrial fission, is overexpressed in response to post-stroke pathologi...