Oct 2026
Oxysophocarpine attenuates acute liver injury by targeting FBP1 to suppress ferroptosis and enhance cellular resilience via the PPARα-GPX4 axis.
Acute liver injury (ALI) is a life-threatening clinical condition with limited therapeutic options. Through network pharmacology screening, we identified oxysophocarpine (OSC), a natural compound derived from traditional Chinese medicine, as a potent reactive oxygen species-scavenging agent. In LPS/D-GalN-induced ALI m...
Jin-Jin Shi, Yan-Jun Liu, Ran Wang et al.
· Free Radical Biology & Medic... · 0 citations