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Li-Ning Peng

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Open access Oct 2026

Regional brain aging signatures predict mortality through neurovascular immune mechanisms.

Brain aging provides an integrative marker of systemic health, but whether regional patterns outperform whole-brain approaches remains unknown. Here, we show that regional brain age signatures achieve superior mortality prediction through identifiable neurovascular-immune mechanisms in 1,240 community-dwelling adults f...

P.-L. Lee, Yi-Long Huang, Chih-Kuang Liang et al. · 0 citations
Open access Aug 2026

Time-dependent biology of mortality in middle-aged and older adults: Distinct predictors for near- and long-term outcomes in a population-based cohort in Taiwan

Objectives Population aging is accompanied by increasing heterogeneity in health trajectories and mortality risk. We aimed to identify and compare independent predictors of 3-year and 5-year all-cause mortality in Taiwanese adults aged ≥50 years, integrating intrinsic capacity (IC), functional status, laboratory biomar...

Chih-Wei Niu, Lin Meng, Hsi-Yu Lai et al. · 0 citations

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