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Author

Li-Ning Zhao

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3 papers indexed here

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Oct 2026

Metformin-loaded multi-enzymatic metal-organic framework nanozyme mediates metabolic reprogramming via multiple energy blockades to boost tumor immunotherapy.

Glycolytic metabolism of tumor cells suppresses the activity of immune cells, and multiple blocking energy supply and remodeling the metabolic microenvironment are important strategies to enhance immunotherapy. Using manganese-doped porphyrin metal-organic framework (MOF) as a carrier, by depositing ultrasmall Au nanop...

Long-Yue He, Tie-Min Li, Li-Ye Wang et al. · 0 citations
Open access Sep 2026

MnPt@metal organic framework nanozyme with photothermal/catalytic dual-strategy enhances Zn2+-mediated immunotherapy through activating pyroptosis and cGAS-STING pathway

Zinc ions (Zn2+) can induce immune response through activating pyroptosis and cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, and disrupting the intracellular redox balance is an important strategy for enhancing Zn2+-driven immunotherapy. Herein, using bimetallic manganese platinum (MnP...

Ze-Kai Li, Qi Zhao, Li-Ye Wang et al. · 0 citations
Aug 2026

Dual-site co-valence cycling nanozyme for boosted cuproptosis and triple-modal photo-catalytic-immunotherapy via redox homeostasis imbalance.

The developed AuMo@Cu2-xSe nanozyme provided a feasible strategy of integrating cuproptosis and photo/catalytic/immunotherapy, significantly suppressing primary and metastatic tumors for breast cancer.

Wei Wang, Zheng Niu, Long-Yue He et al. · 0 citations

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