Scutellaria barbata D.Don suppresses SPP1+ polarization in tumor-associated macrophages via the HIF-1α/STAT3 signaling to attenuate hepatocellular carcinoma progression.
ETHNOPHARMACOLOGICAL RELEVANCE Scutellaria barbata D.Don (SBD) is used for the treatment of hepatocellular carcinoma (HCC) as an alternative therapy in East Asia. Previous studies have shown that SBD can suppress the progression of HCC. However, the precise mechanism of SBD, particularly within the tumor immune microen...