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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Li-Qiang An

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Open access Sep 2026

Gut Microbiota-Derived Butyrate Induces Trained Immunity in Intestinal Macrophages to Potentiate Antitumor Immunity

The gut microbiota metabolite butyrate plays an important role in maintaining intestinal immune homeostasis, but it’s still unclear whether it can induce trained immunity in intestinal macrophages and thus affect anti-tumor immune responses. This study aimed to investigate the ability of butyrate to induce trained immu...

Gang Liu, Jia Wang, Li-Qiang An · 1 citation
Open access Sep 2026

Targeting Mitochondrial Metabolic Reprogramming: Reversing CD8⁺ T Cell Exhaustion and Improving Cancer Immunotherapy Response

This study explores the reversal effect of targeting mitochondrial metabolic reprogramming on CD8⁺ T cell exhaustion within the tumor microenvironment and its synergistic mechanism when combined with immune checkpoint blockade therapy. B16-OVA melanoma and LLC lung cancer tumor-bearing mouse models were established. Us...

Gang Liu, Jia Wang, A. Vasiukevich et al. · 0 citations
Open access Sep 2026

CRISPR Screen and Single-Cell Multi-Omics Identify a Novel Immune Checkpoint on Tumor-Infiltrating Regulatory T Cells

Tumor infiltration regulatory T cells (Tregs) mediate immune escape by highly expressing multiple inhibitory receptors, which is one of the key factors in resistance to existing immune checkpoint inhibitors. However, systematic screening of Treg-specific immune checkpoints within tumors remains lacking. This study aims...

Gang Liu, Jia Wang, Li-Qiang An · 0 citations
Open access Sep 2026

Mitochondrial DNA Sensing Reshapes the Tumor Immune Microenvironment via Cooperative cGAS-STING Activation and Ferroptosis

A new mechanism where mtDNA sensing collaborates with ferroptosis via the cGAS-STING pathway to reshape the tumor immune microenvironment is revealed, providing a theoretical basis and potential targets for developing anti-tumor immunotherapies that jointly regulate innate immunity and ferroptosis.

Gang Liu, Jia Wang, Li-Qiang An · 1 citation

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