Author

Li-Qiang Liu

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Oct 2026

Rational hapten design enables monoclonal antibody-based immunoassays for class-selective detection of phthalate esters in edible oils.

Phthalate esters (PAEs) are frequently detected in edible oils, necessitating rapid detection methods. However, the small molecular size and high structural similarity of PAEs make it challenging to develop antibodies that combine analytical sensitivity with group-selective recognition. Herein, a monoclonal antibody (m...

Qian-Qian Feng, Li-Qiang Liu, Ai-Hong Wu et al. · Food Chemistry · 0 citations

Aug 2026

On-site detection of an emerging fungicide: developing an immunochromatographic assay for thifluzamide through de novo hapten design and synthesis.

Thifluzamide (THF), a novel succinate dehydrogenase inhibitor fungicide, is widely used to control crop diseases; however, excessive residues pose potential risks to human health. To guide hapten design, a detailed analysis of the spatial structures and electrostatic potential distributions of THF and its haptens was c...

Xu-Yang Ma, Aihong Wu, Ling-Ling Guo et al. · Food Chemistry · 0 citations

Sep 2026

A Dual-T-Line Immunochromatographic Assay Based on Computational Chemistry-Guided Hapten Design for Rapid On-Site Detection of Chloroneb in Agricultural and Environmental Samples

The health risks posed by chloroneb (CHL), a representative fungicide, in agricultural products and the environment necessitate rapid detection methods. Here, computational chemistry-aided rational hapten design yielded a high-performance monoclonal antibody against CHL (IC50 = 2.63 ng/mL), guided by analysis of its...

Feng He, Ling-Ling Guo, Mao-Zhong Sun et al. · Journal of Agricultural and... · 0 citations