Author

Li-Rui Yan

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Open access Sep 2026

A novel three-CpG signature for lung adenocarcinoma diagnosis: integrating multi-omics, machine learning, and clinical validation

Background Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality worldwide. The identification of non-invasive biomarkers for early detection is critical to improving patient outcomes. Integrative analysis of DNA methylation and gene expression represents a promising approach for identifying cancer-...

Qian-Ying Liu, Mao-Ting Shen, Li-Rui Yan et al. · Translational Cancer Researc... · 0 citations

Review Open access Sep 2026

CCNE1: A Cell Cycle Regulator That Influences Tumor Progression

ABSTRACT Cyclin E1 (CCNE1), a pivotal member of the cyclin family, governs the G1/S phase transition of the cell cycle by binding to and activating cyclin‐dependent kinase 2 (CDK2), thereby initiating DNA replication and driving S‐phase entry. In a broad spectrum of human malignancies—including breast, ovarian, gastric...

Li-Rui Yan, Si-Yi Liu, Yan-Ling Li et al. · Cancer Medicine · 0 citations