Li-Sha Deng

Secretory expression of tetrameric neuraminidase enhanced by signal peptide optimization elicits robust immunity against influenza infection in mice.

An optimized signal peptide, opt-sp, is developed by introducing valine and asparagine residues at the N-terminus of the Gaussia luciferase signal peptide (Gluc-sp) and incorporating a measles virus phosphoprotein-derived tetramerization domain to identify a promising signal peptide candidate for improving recombinant...