Review
Open access
Sep 2026
Extrachromosomal DNA as a platform for epigenetic reprogramming in cancer
Extrachromosomal DNA (ecDNA) has emerged as a major contributor to cancer aggressiveness, yet its role extends far beyond its classical definition as a vehicle for oncogene amplification. Recent studies indicate that ecDNA functions as a dynamic regulatory platform that reshapes chromatin accessibility, enhancer activi...
Bi-Xia Liu, Lu-Yuan Zhou, Shu-Zhen Lai et al.
· Molecular Cancer · 0 citations