Open access
Aug 2026
Identification of EGFR, MMP9, and AGTR1 as actionable therapeutic targets in acetyl tributyl citrate-driven breast cancer: integrated network toxicology and in vitro validation
In vitro validation revealed that ATBC significantly promoted cell proliferation and migration, and suppressed apoptosis in ER-positive MCF-7 cells, a mechanism driven by profound upregulation of EGFR, MMP9, and AGTR1 mRNA expression.
Bo-Qian Zhou, Li-Si Zhou, Yue Zhang et al.
· Frontiers in Pharmacology · 0 citations