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Author

Li Tang

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Jul 2026

Deciphering the Specificity of Reversible DNA-Phosphate ADP-Ribosylation via the Precise Synthesis and Enzymatic Profiling of Nucleotide-Phospho-ADP-Ribosyl Probes.

The stereoselective synthesis of deoxynucleotide-phospho-ADPr (dN-P-ADPr) probes are reported, representing native fragments of terminal DNA-ADPr, showing that these enzymes exhibit an absolute preference for the native-like α-anomer, independent of the identity of the adjacent DNA nucleobase, suggesting that substrate...

Lingxiao Liu, Yang Lu, Zongxing Yu et al. · 0 citations

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