In vivo and in vitro experiments demonstrated that HDG alleviated renal injury in ADR-induced FSGS in mice and attenuated TGF-β1-induced damage in MPC5 cells, which support HDG as a promising therapeutic candidate for FSGS treatment.
It is found that CPT binds to KLK1, activates its expression, reduces PTEC apoptosis, and thereby attenuates renal fibrosis, and reveals that CPT binds to KLK1, promotes BDKRB2 expression, thereby reducing PTEC apoptosis and improving renal fibrosis.
Jing Gao, Rui-Zhi Tan, K. Deng et al.· Journal of Nutritional Bioch...· 0 citations
Overall, this review highlights the promise of epigenetics-based therapeutic strategies using herbal active ingredients for kidney disease intervention, though further validation and optimization are needed for clinical application.
Qiu-Xiang Bai, Kang Luo, Long-hao Jia et al.· Seminars in Nephrology· 0 citations
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