Author

Li Wang

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Open access Oct 2026

Targeted lactate depletion via gluconeogenesis by engineered hepatocyte-based micronanorobots for radiosensitization and immune activation.

Radiotherapy is often limited by tumor-intrinsic DNA repair and an immunosuppressive microenvironment, both of which are reinforced by lactate accumulation. Here, we develop a CXCR4-engineered enucleated hepatocyte cytoplast platform decorated with Au-Pt Janus nanorobots (AP/LCCXCR4) to deplete intratumoral lactate and...

Yue-Yue Fan, Jia-Min Ye, Yuan-Fang Chen et al. · Cell Reports Medicine · 0 citations

Review Open access Aug 2026

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

This review systematically explores the dual roles of tumor‐associated microbiota‐both promoting and suppressing malignancy‐and highlights the transformative potential of engineered bacterial systems in cancer treatment, and discusses innovative strategies in which bacteria are harnessed to remodel the immunosuppressiv...

Hao-Nan Shen, Weicheng Zhang, Gao-Li Niu et al. · BMEMat · 0 citations