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Author

Li-Wei Zhang

2 papers indexed here

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Sep 2026

H3K27M drives OPC stemness and intrathecal therapeutic vulnerability in brainstem glioma organoids.

Brainstem gliomas, particularly H3K27M-mutant diffuse midline gliomas (DMGs), lack effective therapies owing to anatomic inaccessibility, intact blood-brain barrier, and treatment resistance. Conventional models have low establishment rates and fail to preserve the native tumor microenvironment, limiting translational...

Lu-Yang Xie, Zhuan-Xin Jiang, Hang Zhou et al. · 1 citation
Open access Sep 2026

Synergistic antitumor effect of HMGB2 targeting combined with MDM2 inhibitor in diffuse intrinsic pontine glioma therapy

Diffuse intrinsic pontine glioma (DIPG) is a brain malignancy in children with a dismal prognosis. The high mobility group box 2 (HMGB2) is a member of the HMGB family of chromatin-associated proteins, and is identified as a potential oncogene in various cancers. However, the effects of HMGB2 in DIPG remains unclear. I...

Bo-Chao Zhang, Yuxuan Deng, Lu-Yang Xie et al. · 0 citations

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