Sep 2026
SGK2 Promotes NEDD4L-Mediated ACSL4 Ubiquitination to Inhibit Ferroptosis and Alleviate Diabetic Kidney Disease.
It is found that SGK2 suppresses tubular ferroptosis in DKD through NEDD4L-dependent K48-linked ubiquitination and proteasomal degradation of ACSL4, thereby limiting lipid peroxidation and protecting the renal tubules.
Fei Zhang, An-Dong Zhang, Li-Wen Wang et al.
· Antioxidants and Redox Signa... · 0 citations