Current drugs for ulcerative colitis often face challenges such as significant side effects, high costs, and tendency to induce drug resistance. Repurposing existing drugs is a promising approach that builds on their known safety and efficacy profiles. Artemisinin (Art), a first-line antimalarial agent, shows anti-infl...
Zhi-Qi Zhang, Hao-Ze Song, Yi-Xing Li et al.· Bioorganic chemistry (Print)· 0 citations
Abstract Depletion of cellular NAD+ is an increasingly recognized bacterial antiphage strategy, and many phages counter this pressure by rebuilding NAD+ from its cleavage products. In the NARP1 pathway, Adps converts ADP-ribose (ADPR) and ATP into ADPR-PP, the immediate substrate for Namat-dependent NAD+ synthesis, but...
This review comprehensively evaluates APS extraction, structural characterization, biological activities, and application, with particular emphasis on the evidence linking preparation-dependent structural variation to biological responses.
Jing Cheng, Qian-Hui Liu, Rui Zhu et al.· International Journal of Bio...· 0 citations
The design and synthesis of SHP2 PROTACs that recruit the DCAF16 E3 ligase for targeted SHP2 degradation are reported that support the potential of SHP2-targeted protein degradation as an alternative strategy to enzymatic inhibition and provide a promising starting point for the further development of SHP2 degraders.
X. Pang, Yuxin Gan, Qing-Yuan Hu et al.· Bioorganic chemistry (Print)· 0 citations
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