An acidic pH-activatable fluorescent probe for MUC1 detection and the precise imaging of MCF-7 cells.
Mucin 1 (MUC1), a pivotal cancer biomarker, is overexpressed on MCF-7 cells, which has stimulated the construction of numerous aptamer-based fluorescent probes for breast cancer diagnosis. However, MUC1 is also present in the serum of cancer patients and expressed at low levels on the surface of normal cells, which may...