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Li-Xuan Zhu

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Open access Sep 2026

Disruption of CTCF-mediated IGF2 repression promotes AKT-dependent mitochondrial oxidative stress and chondrocyte senescence in osteoarthritis.

Findings support a functional regulatory framework linking CTCF-IGF2 dysregulation with AKT-dependent mitochondrial oxidative stress and chondrocyte senescence in OA, highlighting IGF2 signaling as a potential therapeutic target.

Chun-Pan Zhang, Fei Xu, Jiang-Ping Wu et al. · 0 citations

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