Author

Li-Ya Liang

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Open access Sep 2026

DyProL: Dynamic Ensemble Representation Learning for Protein–Nucleic Acid Binding Site Prediction

ABSTRACT Protein–nucleic acid interactions play central roles in gene regulation and cellular function, and extensive efforts have been devoted to predicting nucleic acid binding sites from protein structures. However, protein–nucleic acid recognition is inherently dynamic, whereas most existing computational approache...

Pengpai Li, Yi-Man Liu, Li-Ya Liang et al. · Advancement of science · 0 citations

Aug 2026

Global transcriptional rewiring and dual-compartment engineering for efficient 3-hydroxypropionic acid production in Saccharomyces cerevisiae.

This work establishes a generalizable framework for multi-compartment malonyl-CoA utilization in eukaryotic cell factories through dynamic control of HFA1 and optimized POS5 expression, and develops a dual-compartment coordination strategy to efficiently exploit cytosolic and mitochondrial malonyl-CoA pools.

Jing Liu, Huiping Tan, Xi Deng et al. · Metabolic Engineering · 0 citations

Open access Aug 2026

A self-iterative orthogonal base-editing platform enables multiplex N-to-N diversification and genome-scale functional screening in Escherichia coli

MUTATOR is reported, a MUlTiplexAble and self-iTerative ORthogonal base-editing platform that enables N-to-N diversification in Escherichia coli and is established as a broadly applicable platform for genome-wide diversification, functional dissection, and rapid engineering of industrial microbial chassis.

Xiangrui Fan, Li-Ya Liang, Hongle Wang et al. · Nucleic Acids Research · 0 citations