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Bladder cancer is characterized by redox adaptation and metabolic plasticity, but the mechanisms linking these processes remain incompletely understood. Integrating bulk, single-cell, and spatial transcriptomic analyses, we identified PRDX1 as a malignant epithelial cell-associated factor linked to adverse outcome. Gen...
This study links resistance-associated cellular states to a functionally validated regulator and provides an integrative framework for identifying clinically relevant regulators of chemotherapy resistance in bladder cancer.
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