Li Yang

Lysine lactylation in glioma: from metabolic stress to epigenetic remodeling and therapeutic resistance

Glioma is characterized by profound metabolic reprogramming and sustained lactate accumulation; however, the mechanisms by which lactate-rich metabolic stress is translated into stable malignant phenotypes remain incompletely understood. Lysine lactylation (Kla), a recently identified post-translational modification, h...