Author

Li Yuan

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Open access Oct 2026

The synthesis of niclosamide derivative as a novel colistin adjuvant for reversing colistin resistance and its antibacterial activity with colistin in vitro

ABSTRACT Colistin (COL) serves as a last-line therapeutic agent against multidrug-resistant gram-negative bacteria (GNB) infections. Nevertheless, widespread clinical use of COL has led to severe bacterial resistance. The anthelmintic drug niclosamide (NIC) has been shown to enhance the activity of COL in combination t...

Pei-Yi Liu, Ying-Biao Li, Fan-Lun Ding et al. · Msphere · 0 citations

Open access Oct 2026

Stepwise evolution of tigecycline resistance in Enterococcus hirae through early IS1216E-mediated tet(L) amplification and subsequent rpsJ mutations

Enterococcus spp. from food animals represent important reservoirs of antimicrobial resistance; however, the mechanisms underlying tigecycline resistance remain poorly understood. In this study, we investigated the genetic basis and evolutionary dynamics of tigecycline resistance in Enterococcus hirae. Among 118 Entero...

Yan-Bin Dong, Zhong-Yi Fang, Zheng-Yu Wei et al. · Veterinary Research · 0 citations