F-53B drives placental inflammation via an IL1R1-mediated NLRP3 inflammasome activation: Evidence from epidemiology and a laboratory experiment.
Our prior work suggested that gestational exposure to chlorinated polyfluorinated ether sulfonates (F-53B) induces placental inflammation by activating the NLRP3 inflammasome, but the primary molecular target remains unclear. This study examined whether interleukin-1 receptor type 1 (IL1R1) served as a key target in F-...