Li Zhu

A Review on the Structural Evolution and Clinical Evidence of Boronic Acid β-Lactamase Inhibitors

The spread of carbapenem-resistant Gram-negative bacilli has made β-lactam/β-lactamase inhibitor (BLI) combinations central to therapy. Boronic acids are the only BLI class whose chemistry can in principle reach all four Ambler classes, boron forms a tetrahedral adduct with the catalytic serine and can also coordinate...