Succinylation-related gene GLS regulates mannose and glycerophospholipid metabolism to promote irritable bowel syndrome: an integrated study combining Mendelian randomization, SMR, and mediation analysis
To investigate whether succinylation-related genes participate in irritable bowel syndrome (IBS) pathogenesis by regulating blood metabolites. Genome-wide association study (GWAS) data for cis-expression Quantitative Trait Loci (cis-eQTLs) were obtained from eQTLGen Consortium. Blood metabolite GWAS data were derived f...