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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Lian Wu

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Oct 2026

A Substrate-Permissive Vanadium Haloperoxidase in Type II Polyketide Biosynthesis Unlocks Non-Native Halogenation across Diverse Substrate Scaffolds

Halogenated compounds are prevalent in natural and synthetic molecules, profoundly affecting molecular stability, physicochemical properties, and biological activity. While enzymatic halogenation offers a sustainable and selective synthetic route, its broad application is limited by the narrow substrate scope of the...

Shi-Qi Fang, D. Ding, Qiu-Yue Nie et al. · 0 citations
Sep 2026

Biosynthesis of YM-216391 Unveils a Bifunctional α-Ketoglutarate-Dependent Enzyme Catalyzes Hydroxylation and Epimerization in RiPPs

The RiPP-modifying enzyme YmI is reported, a bifunctional Fe/αKGD that catalyzes Cβ-hydroxylation of Phe19 and Cα-epimerization of Ile20 on the precursor peptide YmA toward the formation of YM-216391, unveiling an unprecedented mechanism and novel bifunctionality, markedly expanding the reaction landscape for αKG-depen...

Kai Zhang, Lian Wu, Min-Jie Yang et al. · 0 citations

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