The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway represents a pivotal innate immune signaling axis that bridges cytosolic DNA sensing with type I interferon and pro-inflammatory cytokine production. However, the clinical translation of STING agonists, particularly cyclic dinucleotides (...
Yun-Qi Guo, Zhi-Hao Zhao, Liang-Can He et al.· ACS Nano Medicine· 0 citations
Radioimmunotherapy holds great promise for the treatment of solid tumors. However, radioresistance and immunosuppression mediated by a tumor microenvironment (TME) severely restrict radiation-induced immunogenic cell death (ICD), facilitate tumor relapse and metastatic dissemination, and ultimately compromise the the...
Yunsong Wang, Nannan Zheng, Shujuan Liu et al.· ACS Nano· 0 citations
In vivo studies in diabetic Sprague-Dawley rats model demonstrated that CC-pMnO2-Vet@PNAA established a coordinated immune-mechanical microenvironment, achieving rapid and scar-free wound healing.