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Author

Liangcan He

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Review Sep 2026

Beyond Agonist Delivery: Metallic Nanomaterials as Active Regulators of cGAS-STING Signaling in Cancer Immunotherapy

The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway represents a pivotal innate immune signaling axis that bridges cytosolic DNA sensing with type I interferon and pro-inflammatory cytokine production. However, the clinical translation of STING agonists, particularly cyclic dinucleotides (...

Yun-Qi Guo, Zhi-Hao Zhao, Liang-Can He et al. · 0 citations
Aug 2026

X-ray-Responsive Cascade System for Radioimmunotherapy: Tumor Microenvironment Remodeling and Controllable NO Release

Radioimmunotherapy holds great promise for the treatment of solid tumors. However, radioresistance and immunosuppression mediated by a tumor microenvironment (TME) severely restrict radiation-induced immunogenic cell death (ICD), facilitate tumor relapse and metastatic dissemination, and ultimately compromise the the...

Yunsong Wang, Nannan Zheng, Shujuan Liu et al. · 0 citations
Open access Aug 2026

A Hierarchical Hydrogel Modulates Immune‐Mechanical Microenvironments to Spatiotemporally Reprogram Fibroblasts for Scarless Diabetic Wound Healing

In vivo studies in diabetic Sprague-Dawley rats model demonstrated that CC-pMnO2-Vet@PNAA established a coordinated immune-mechanical microenvironment, achieving rapid and scar-free wound healing.

Shuang-Li Zhu, Qiu-Yue Ma, Ayang Zhao et al. · 0 citations

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