Vitamin K3 attenuates STING-agonist-induced signaling and imiquimod-induced psoriasis-like inflammation.
Cytosolic DNA sensing through the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) axis is an important component of innate host defense, whereas sustained pathway activation has been implicated in inflammatory and autoimmune diseases. Although several potent STING inhibitors are in preclinical devel...