Author

Liang Kang

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Open access Aug 2026

Single-cell and spatial transcriptomics characterisation of RSPO2+ nucleus pulposus cells reveals a WNT/FN1–CD44 degenerative axis and therapeutic targets in IVDD

This study identifies an RSPO2-associated NP state and a candidate WNT/FN1–CD44 programme linked to IVDD, and provides a testable basis for future WNT-directed intervention studies while recognising the limits of acute rat models and cross-species data.

Qiu-Wei Li, Guoyan Liang, Kai-Da Bo et al. · Journal of Orthopaedic Trans... · 1 citation

Open access Jul 2026

MANF safeguards mitochondria-associated endoplasmic reticulum membrane integrity in nucleus pulposus-derived mesenchymal stem cells to maintain homeostasis of the intervertebral disc.

BACKGROUND Intervertebral disc (IVD) degeneration (IDD) is a leading cause of low back pain, with limited treatment options. The degenerative disc's harsh microenvironment promotes nucleus pulposus-derived mesenchymal stem cells (NP-MSCs) death and hinders self repair. Mesencephalic astrocyte-derived neurotrophic facto...

Chen-Hao Zhao, Liang Kang, Jiaqi Wang et al. · Cell Biology and Toxicology · 0 citations

Open access Jul 2026

Hounsfield unit measurements from different regions of interest in lumbar spine CT: correlation with DEXA-derived bone mineral density and fracture status.

Different lumbar CT ROI methods demonstrated comparable performance in assessing BMD and discriminating thoracolumbar fragility fracture status, and sensitivity analysis confirmed that exclusion of substituted vertebral levels did not materially affect the results.

Zengkai Zhou, Jia-Qi Wang, Lu-Ping Zhou et al. · BMC Musculoskeletal Disorder... · 0 citations