Author

Liang-Kung Chen

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Sep 2026

Serum biomarkers, modifiable risk factors, cognition, and processing speed in older adults.

BACKGROUND Cognitive impairment is a major public health concern in aging populations. However, most previous studies have examined serum biomarkers and lifestyle, psychosocial, and clinical factors in isolation, and their associations with global cognition and processing speed remain unclear. The aim of this study was...

Chia-Te Chen, Fong-Ping Tang, Chia-Hao Fan et al. · Journal of the Chinese Medic... · 0 citations

Open access Oct 2026

Regional brain aging signatures predict mortality through neurovascular immune mechanisms.

Brain aging provides an integrative marker of systemic health, but whether regional patterns outperform whole-brain approaches remains unknown. Here, we show that regional brain age signatures achieve superior mortality prediction through identifiable neurovascular-immune mechanisms in 1,240 community-dwelling adults f...

P.-L. Lee, Yi-Long Huang, Chih-Kuang Liang et al. · Cell Reports Medicine · 0 citations

Open access Aug 2026

Time-dependent biology of mortality in middle-aged and older adults: Distinct predictors for near- and long-term outcomes in a population-based cohort in Taiwan

Objectives Population aging is accompanied by increasing heterogeneity in health trajectories and mortality risk. We aimed to identify and compare independent predictors of 3-year and 5-year all-cause mortality in Taiwanese adults aged ≥50 years, integrating intrinsic capacity (IC), functional status, laboratory biomar...

Chih-Wei Niu, Lin Meng, Hsi-Yu Lai et al. · The Journal of Nutrition, He... · 0 citations