Open access
Sep 2026
Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma
ABSTRACT Glioblastoma multiforme (GBM), the most lethal type of primary brain tumor, exhibits profound metabolic plasticity driven by glioma stem cells (GSCs), which sustain therapeutic resistance and tumor recurrence. Here, we elucidate a novel epigenetic‐metabolic axis mediated by the histone acetyltransferase KAT7 t...
Ji-Long Liu, Yan-Fei Sun, Yue-Hua Zhu et al.
· Advancement of science · 0 citations