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Brainstem gliomas, particularly H3K27M-mutant diffuse midline gliomas (DMGs), lack effective therapies owing to anatomic inaccessibility, intact blood-brain barrier, and treatment resistance. Conventional models have low establishment rates and fail to preserve the native tumor microenvironment, limiting translational...
Pediatric meningiomas display a distinct clinical profile characterized by frequent imaging misdiagnosis, high proportion of intraventricular/parenchymal location, and elevated high-grade pathology.
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