Review
Open access
Aug 2026
Microglia-mediated neuroinflammation in Alzheimer’s disease: mechanisms and emerging therapeutic targets
A “cellular state–pathological network–therapeutic window” framework is proposed and the roles of microglia in amyloid-β plaque seeding and compaction, NLRP3 inflammasome activation, mitochondrial DNA–cGAS–STING signaling, complement-mediated synaptic engulfment, and bidirectional microglia–tau feedback are systematically discussed.
Lian-Jing Xu, Ying Zhang, Li Jiang et al.
· Frontiers in Cellular Neuros... · 0 citations