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Small-molecule NUAK inhibitors are in development, several of which have been shown to reactivate Hippo signaling, restore YAP/TAZ cytoplasmic retention, and suppress aberrant cancer cell proliferation and fibrosis.
Summary A major hurdle in Alzheimer disease research is the failure of mouse models to capture complexities of the human brain that contributes to repeated clinical trial failure. Although the recent US Food and Drug Administration (FDA) Modernization Act 2.0 has enabled non-animal preclinical pathways, brain organoid...
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