Review
Open access
Sep 2026
Beyond hypoxia and ccRCC: the expanding universe of VHL novel targets and next-generation therapeutics
The von Hippel-Lindau (VHL) gene encodes the core substrate-recognition subunit of the Cullin2-RING E3 ubiquitin ligase complex, regulating cellular oxygen sensing and proteostasis. While targeting the canonical VHL-hypoxia-inducible factor (HIF) axis (e.g. belzutifan) has improved advanced clear cell renal cell carcin...
Rui-Yi Deng, Bo-Yuan Wang, M. Zou et al.
· Biomarker Research · 0 citations