Author

Lin-Feng Li

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Open access Sep 2026

High‐throughput identification of carboxylate‐free ligands for the E3 ligase Kelch domain‐containing protein 2

It is demonstrated that KLHDC2 can accommodate non-carboxylate scaffolds and expands the chemical space for developing KLHDC2-based targeted protein degradation strategies and expands the chemical space for developing KLHDC2-based targeted protein degradation strategies.

Yao Chen, Rui-Chen Gao, Jia-Jia Li et al. · Protein Science · 0 citations

Review Open access Sep 2026

Monovalent Nondegrading Molecular Glues: An Updated Overview of Emerging Mechanisms and Therapeutic Development

The ndMG modality represents a highly versatile strategy to unlock the undruggable proteome and is systematically highlighted to highlight their evolving capabilities to modulate oncogenic networks, intervene with immune activity, rectify metabolic signaling, control neurodegenerative trafficking and stress networks, a...

Lin-Feng Li, Jia-Jia Li, Li Yang et al. · Pharmaceuticals · 0 citations

Jul 2026

Structure-Guided Discovery of Novel Dual-Site FEM1B Ligands and Assessment of Their Use in Targeted Protein Degradation.

This work developed FL47, a dual-site ligand that combines extensive noncovalent interactions with targeted covalent engagement that exhibits submicromolar affinity, robust cellular target engagement, and markedly reduced cytotoxicity relative to previously reported covalent recruiters.

Ling-xiang Xu, Ruyi Huang, Yu-Ying Ma et al. · Journal of Medicinal Chemist... · 0 citations