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Author

Lin Hu

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Open access Sep 2026

HDAC4 drives ferroptosis and fibrosis by inhibiting Foxo3a-GPX4 axis during AKI–CKD progression

Histone deacetylase 4 (HDAC4) modifies both histone and non-histone proteins, but its role in the transition from acute kidney injury (AKI) to chronic kidney disease (CKD) remains unclear. Here, we investigated the function and mechanism of HDAC4 in ischemia-reperfusion (IR)-induced AKI-CKD progression using Tasquini...

Feng-Chen Shen, Lin Hu, Xin-Yu Du et al. · 0 citations
Aug 2026

METTL4 knockout alleviates sepsis-induced liver injury via inhibiting NCOA4-mediated ferritinophagy and ferroptosis.

It is demonstrated that the methylation level is highly expressed in the septic liver injury, complying with the up-regulation of m6A methyltransferase METTL4 and the reader YTHDF1, and provides a potential therapeutic target to treat sepsis-induced liver injury.

Qiong Luo, Ling Li, Zhe Jin et al. · 0 citations

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